Multiple Sclerosis Lesions and Irreversible Brain Tissue Damage
نویسندگان
چکیده
منابع مشابه
Multiple sclerosis lesions and irreversible brain tissue damage: a comparative ultrahigh-field strength magnetic resonance imaging study.
BACKGROUND In current clinical practice, T2-weighted magnetic resonance imaging (MRI) is commonly applied to quantify the accumulated multiple sclerosis (MS)lesion load, whereas T1-weighted sequences are used to differentiate edema, blood-brain barrier breakdown by contrast enhancement, and irreversible brain tissue damage(commonly called “black holes” owing to the loss of signal intensity in T...
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Multiple sclerosis is a chronic inflammatory disease of the central nervous system, associated with demyelination and neurodegeneration. The mechanisms of tissue injury are currently poorly understood, but recent data suggest that mitochondrial injury may play an important role in this process. Since mitochondrial injury can be triggered by reactive oxygen and nitric oxide species, we analysed ...
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One of the histological hallmarks of early multiple sclerosis lesions is primary demyelination, with myelin destruction and relative sparing of axons. On the other hand, it is widely accepted that axonal loss occurs in, and is responsible for, the permanent disability characterizing the later chronic progressive stage of the disease. In this study, we have used an antibody against amyloid precu...
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Sir, To correlate magnetic resonance imaging (MRI) patterns with tissue destruction is interesting, but to correlate MR patterns with ongoing inflammation to predict the fate of a lesion is of great importance in clinical practice of Multiple sclerosis (MS). The paper of Nessler et al. (2007) reporting early and predictive MRI changes in a mouse model of MS is therefore of great interest. The p...
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OBJECTIVE Axonal damage occurs early in multiple sclerosis (MS) and contributes to the degree of clinical disability. Children with MS more often show disabling and polyfocal neurological symptoms at disease onset than adults with MS. Thus, axonal damage may differ between pediatric and adult MS patients. METHODS We analyzed axonal pathology in archival brain biopsy and autopsy samples from 1...
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2012
ISSN: 0003-9942
DOI: 10.1001/archneurol.2011.2450